There is a clear correlation between the exhibition industry and the various sectors of national economy. Large-scale exhibition activities are significant to the promotion of regional industrial levels and the upgrading of industrial structures. Based on the data of 986 listed companies in Jiangsu, Zhejiang and Shanghai, we took the 4th China International Import Expo (CIIE) as the research object, and used the case study method to empirically analyze the impact of CIIE on different sub-sectors in Jiangsu, Zhejiang and Shanghai. The results showed that: CIIE can promote the development of regional industry and play an active role in the upgrading of regional industrial structure; There are significant differences in the impact of the CIIE on different sub-sectors in the region, among which the promotion of high-tech industry, manufacturing industry and service industry is more obvious;The effect of the CIIE on infrastructure-related industries tends to rise first and then decline. This paper explores the impact of large-scale exhibitions on the development of different industries in the region at the micro level, in order to provide a policy reference for the development of the exhibition industry.