The four breakthrough tests was enforced in three towns for exploring the methods of preventing schistosomiasis from 2004 to 2008 year.The results showed that these tests got conspicuous effect on killing oncomelania,preventing schistosomiasis and bringing big economic benefit;the area with oncomelania decreased 53.11%;the infection rate of human decreased 0.23%;the infected rate of animal decreased 0.41%.These tests brought 39,696,500 yuan incremental income after they were generalized in 51 villages.