With the continuous enhancement of environmental awareness， Hefei gradually learned from the management experience of other cities and began to pay attention to the comprehensive disposal of construction waste. However，there are very few construction waste disposal enterprises， and the utilization rate of resources is low. This paper takes two disposal modes of construction waste landfill and comprehensive disposal as the research object，uses the life cycle assessment method to establish an evaluation model，combines the relevant research status with the basic data of Hefei city，and uses the CMLCA software to compare and analyze the environmental load value， ecotoxicity and other indicators of construction waste under the two modes of landfill and comprehensive disposal from the perspective of environmental benefits. Therefore，it is concluded that the environmental benefits of construction waste after comprehensive disposal are bigger and it has a good development prospect. More citizens and entrepreneurs are encouraged to participate in the comprehensive disposal of construction waste in Hefei City and to improve the comprehensive utilization rate. Through analysis， it is found that the side effect of the brick manufacture in the comprehensive disposal process on the environment is serious， so it is necessary to improve the brick making process and reduce energy consumption.