The stamping of S-shaped cross-section structural parts of rail vehicles often produces spring-back deformation， which will cause holes in the parts and secondary form and position errors of local shapes. Taking the S-shaped cross-section structure of railway vehicle as the object， referring to the blank layout design process， through the process analysis and CAE simulation analysis， the ten-process layout of blank is preliminarily designed； The design purpose of each process of blank layout is analyzed in detail from the perspective of forming process and mold outline design； According to the designed blank layout， the progressive die design is completed， and the real stamping test is done on the designed， manufactured and debugged progressive die. The results show that the designed layout of ten processes is suitable for the stamping process of S-shaped structural parts of rail vehicles. The popularization and application of the blank layout design method and scheme should have good economic and social benefits.