The application of information technology in the teaching practice in colleges and universities is the inevitable result of the development of education. The Rain Classroom as an interactive teaching platform integrates information technology and classroom teaching profoundly. In order to improve the teaching quality of organic chemistry classes in the teaching reform practice of Xichang University, this paper analyzes the teaching characteristics and status of organic chemistry, tries on the application of Rain Classroom in organic chemistry, and then expounds the effect and existing problems of applying Rain Classroom in teaching. The results show that the application of Rain Classroom can improve students’ learning efficiency, class involvement, concentration and other aspects by supervising the classroom teaching effectively. 84.78% of the students hope to continue to use Rain Classroom in the future, and hold a positive attitude about whether Rain Classroom can improve the teaching effect. The application of Rain Classroom in organic chemistry teaching has achieved good results, which serves the curriculum teaching reform of colleges and universities in the new era.