In order to meet the requirements on logistics professional talents training in application-oriented university, the evaluation mechanism of the curriculum learning effect should be systematically discussed. Based on the analysis of the current situation of the evaluation of the curriculum learning effect of the Logistics System Analysis, the CDIO concept is used for reference, the improvement of students' ability is taken as the main line, and the evaluation indicators are selected from the whole life cycle of teaching practice. The evaluation system of the curriculum learning effect is constructed and implemented in teaching practice. The teaching practice shows that the above method achieves the comprehensive evaluation of the whole teaching process by promoting students' abilities and learning effects. The research provides a new perspective and path for the improvement of curriculum teaching, which can provide reference for the reform of curriculum teaching form and the evaluation of teaching effect.