Based on the orientation of education objectives for application-oriented talents and OBE (Outcome-Based Education) education idea in application-oriented universities, the curriculum of Applied Geochemistry was reformed in terms of teaching materials, teaching methods, teaching organization forms and assessment methods. The teaching materials are added with local special engineering examples and are modularized, the project-driven teaching method is adopted, the teaching organization form is a combination of class teaching and personalized instruction, and a process assessment has been added to the assessment methods. After two years of practice, the curriculum reform has improved students' overall ability for knowledge acquisition and teamwork. Research results can provide some guidelines for the curriculum reform in similar universities.