[Objective] To investigate the effect of intervention on body shape and cardiopulmonary function of obese female college students. [Methods] Forty-eight obese female university students majoring in non-physical education in Anhui Wenda Information Engineering College were selected as research objects and divided into control group and experimental group (24 students in each group) for a 4-month exercise intervention experiment. The indexes of the subjects were tested before and after the experiment, and the results were compared and analyzed. [Results] Before intervention, there was no significant difference in the indicators between the two groups; before and after intervention, there were significant differences in body circumference, skin pleat thickness and in cardiopulmonary function except in height; there was no significant difference in the indexes of the control group before and after intervention; after the intervention, except for the height of the experimental group and the control group, other indicators were significantly improved. [Conclusion] The intervention mode of aerobic exercise combined with strength training can reduce the body fat content, reduce the body circumference and skin fold thickness of obese female college students, and improve their cardiopulmonary capacity.