Aiming at the construction of Maker's laboratory in vocational colleges, two-dimension high-skilled talent cultivation model is explored from the aspects of professional skills and entrepreneurial ability. This paper analyzed the environment and content construction of Maker's laboratory suitable for vocational colleges, which carry out the closed loop of teaching project, social service and mobile internet innovation, professional skills is promoted by Maker Movement. Through the talent cultivation model, the environment and activities of Maker's laboratory, the integration of teaching, the connotation construction of Maker's laboratory had carried out in-depth practice and summary.