The development of animation major in higher vocational colleges is facing opportunities and challenges under the background of "Internet + animation". Through carding, induction and summary of a variety of innovative practice model of animation talent training, the optimization strategy of animation talents training mode in higher vocational education is proposed: it is mainly from the strengthening of the connotation construction of animation major in higher vocational education to promote the depth of cooperation between schools and enterprises, and the integration of production and education, so as to improve the quality of animation talents training and to promote the healthy development of animation major in higher vocational colleges