This paper analyzes the teaching problems for now, and proposes the importance of the cooperation between enterprises and universities, and analyzes the necessity of teaching reform of enterprise application software development in computer science and technology. Applied talents training is strengthened by means of integration of computer software development standards under the existing curriculum system. The professional ability is decomposed to six basic skills according to job requirements, and the modular curriculum system has been established. The importance of cooperation between universities and enterprises was strengthened, and the foundation for the cultivation of applied talents in the joint training has been established.