By extracting the medical statistics date from January to Augusta of 2014 in a hospital, this article then measured out the 95% confidence interval of the open sickbeds of all clinical departments of the hospital. Optimizing adjustment was conducted on the allocation of hospital beds in a hospital combined with the indexes of sickbeds work efficiency and admission number of every 100 visits. The sickbeds arrangement in five departments were reasonable in all the fourteen clinical departments, ward of heart head blood-vessel、the second surgical ward 、 the first Orthopedic ward and gynecology ward needed to increase sickbeds, diabetes ward、spleen and stomach ward、tumor ward、the third orthopedic ward and acupuncture wards needed to reduce beds. To calculate the goal open sick bed s number according to work efficiency index of each department and make relevant reason adjustment to the sickbeds can optimize the allocation of medical resource and improve the social and economic benefits of the hospital at the same time.