As the research area of the four regions of Wuhu City in Anhui Province (Jinghu region, Yijiang region, Jiujiang region, Sanshan region),use of the 1994 Landsat-5 TM image, 2006 and 2014 Landsat-7 ETM + image solution results, aquired of Wuhu City, four regions land use / cover classification map, and based on envi image analysis and mathematical statistics method of Wuhu City, four region 1994-2014 land use / cover change to do quantitative analysis of various land use types between the mutual transformation relationship, to explore the main reason for the changes in various area. Research for the further development of the city planning and construction has a certain reference.