Subway is a city miniature of history, culture, economy and art. Hefei subway construction has become a highlight of livelihood projects. In the process of the construction ,the subway signage system is a complex and systematic design engineering. This article will focus on the development of Hefei subway guides system design, in combination Hefei geographical and cultural characteristics, while the establishment of design elements and the direction of its guides system. The article aims at subway guides system design research and development work from the quality point of view, so that the subway system meets the guiding function while also demonstrate Hefei city unique charm .