The writer of this paper draws lessons from teaching experience of foreign animation design and production major，analyzes the present situation of the teaching mode of animation design and production major in higher vocational colleges in our country and points out that the university-enterprise cooperation is the reform trend. University-enterprise cooperation is mutually beneficial to school and enterprise and can achieve win-win result. The school can make use of the resources of the enterprise to solve the problem of the shortage of teachers， facilities and technology；Enterprises can take advantage of the resources of the school to solve the problem of employing staff，scientific research and product promotion. Through the study of university-enterprise cooperation teaching mode，we can improve the cultivation path of cultivating employment-oriented applied talents specializing in animation.