Information literacy is particularly important for a person in the information age. The traditional face-to-face or online education teaching mode which the university libraries adopt existed some inevitable shortages, such as limited teaching resources, long-time teaching and learners’poor experience. The author put forward the On-line and Offline teaching mode of MOOC platform which combined autonomous learning of MOOC courses with teacher’s guidance operating learning in the computer room. This paper focused on the teaching process and characteristics of the new mode, at the same time, more serious requirements were set for teachers.