In this paper, by means of Mawhin＇s continuation theorem, we study a kind of fourth-order p-Laplacian differential equation with delay as follows ：（φp（x″（f）））″＋f（x′（t））＋β（t）g（t,x（t）,x（t-τ（t））,x′（t））=e（t） A new result on the existence of periodic solution is obtained. Our results are different from the previous literatures, the equation considered is more general, which make the results have much more profound meaning.