In this study,we use river sand with different particle size as the base material for compound-combin ation,and research seedling cultivation technology of flue-cured tobacco based on sand breeding and float-breeding.The result indicates that comparing with current float seeding cultivation,the technology using sand with different particle size as the base material for compound-combination can make the rate of emergence and the planting percent higher,the emerged seeding grow robust in good order and with developed root system and more dry matter;the growth period and the incidence rate of spiral root stay same with the current float-breeding,and the entire quality of seeding plant is higher than comparison.The incidence rate of spiral root with 100 percent river sand as the base material is higher than comparison,while the growth period is delayed about 2 to 3 days and the sand-missing rate is higher than that after compound-combination.But the entire quality of seeding plant keeps almost the same with the comparison.Therefore,comparing synthetically,the T6（2.5mm river sand perlite： vermiculite = 8 ：1 ：1）is the best condition.