Under nowadays＇ socio-economic circumstances, the vocational guidance in universities is of significant strategic meanings. Collection and application of vocational information scientifically is an important part of vocational guidance work in universities. Based on analyzing the relationship of vocational information collection and vocational guidance, this paper tries to study the methods, principles and channels of vocational information collection, and further discuss how to effectively make use of vocational information as to carrying out vocational guidance work.