As a particular retrovirus,lentivirus possess several advantages such as the capability of infection to dividing cell as well as Unseparated Cell,a large capacity of metastatic gene fragment,a long time of expression of purpose gene and difficult to induce the immune reaction of host and so on when compared with the usually used vectors such as retroviral vector and adenovirus vector,and it becomes to be the hot spot of the vector research in present gene therapy and transgenic animals.It has got certain progress in the research of basic bionomics,vector transforment and application.So it provides an overview of the research in vector construction and applications in the article.