Green synthesized iron nanoparticles （Fe NPs） by Euphorbia Cochinchensis extract have high application potential in the field of water environment remediation. However, due to the agglomeration, easy oxidization and other unstable factors of Fe NPs, the reaction activity was inhibited in the removal of pollutants. To solve this problem, kaolin-supported Fe NPs (K-Fe NPs) were prepared and their reaction activity has been tested systematically on the removal of mixed contaminants malachite green and Pb²⁺. X-ray diffraction (XRD) and Fourier Translation Infrared Spectroscopy (FTIR) were used to characterize Fe NPs, Kaolin, and K-Fe NPs. The comparative experiment results of three materials demonstrated that the removal efficiency on individual malachite green and Pb²⁺ using K-Fe NPs (99.10% and 93.41%) was better than Fe NPs (93.67% and 85.33%) and Kaolin (32.54% and 12.50%). Furthermore, the removal efficiencies of four reuse cycles were still 74.02 % and 55.48% on malachite green and Pb²⁺ respectively. In conclusion, K-Fe NPs has certain application prospects in the field of dye and heavy metal ion composite pollution remediation.