In order to ensure the rationality of the location of logistics distribution center， save the distribution mileage and reduce the cost of distribution， this paper combines the clustering-gravity method and CFLP（Capacitated Facility Location Problem） model to study the location of urban logistics distribution center. Firstly， the distribution area is divided by the shortest distance clustering method. Secondly， based on the CFLP model and clustering results， the secondary logistics distribution centers are selected based on the principle of minimization of logistics distribution costs. Then， the coordinates of the two first-level logistics distribution centers are obtained by using the center of gravity method for the second-level logistics distribution centers and all the regional logistics distribution centers in the city. Finally， the total distribution distance and total distribution cost of the two first-level distribution centers are calculated， and the comparative analysis is carried out. The results show that it is the most reasonable to choose the first level logistics distribution center which is obtained by using the center of gravity method for the second level logistics distribution center as the final first level logistics distribution center， and the method can be applied to the location selection process of the distribution center of the second level logistics.