Under the background of the new agricultural science education， the special fruit tree science course group of Huaibei Normal University developed online and offline teaching resources as the basis， and made use of professional talent training programs to reform and innovate teaching content and methods from the starting point of "student-centered and teaching effectiveness oriented". Information technology platforms were used to accurately manage courses， diversified teaching methods were adopted for long-term practical research， and first-class courses were created with distinctive features in horticulture. In order to better achieve teaching effectiveness， the course adopted a mixed online and offline teaching approach. Through analyzing the current teaching situation of the course， diverse teaching methods such as enriching teaching methods， optimizing course content， arranging teaching progress reasonably， connecting online and offline teaching， emphasizing the integration of ideological and political elements， combining practical activities， and establishing multi-dimensional learning evaluations， were adopted to stimulate students'' active learning interest and improve the teaching effectiveness of this course. It has been proven that innovative teaching methods implemented in the curriculum have effectively improved teaching effectiveness， enhanced students'' learning autonomy， comprehensive practical abilities， and academic performance.