In order to analyze the correlation between the ionospheric TEC anomalies and the Luding M_S6.8 earthquake，based on the GFZ global ionosphere map from August 6th to September 8th，2022，we selected four key points and employed the sliding quartile range method to detect the VTEC anomalies over the epicentral region of the Luding M_S6.8 earthquake on September 5th, 2022. The VTEC at the four selected key points exhibited anomalous disturbances on August 26th， August 30th， September 4th， September 5th， and September 8th. After excluding the interference of spatial environmental activities， the negative anomaly on August 26th and the positive anomaly on August 30th were found to be correlated with this earthquake，Furthermore， the VTEC anomalies were concentrated between UT04：00 and 12：00， exhibiting a characteristic of initial increase followed by decrease. The detection results demonstrate a strong correlation between the ionospheric TEC anomalies during the earthquake and the seismic event itself， and can provide valuable reference for earthquake prediction and analysis.