The Fe in Titanium Gypsum is the major factor for its usability.The P507 extraction and acetone method were compared to find the optimal purification technology from Titanium Gypsum.The results showed,under the optimal conditions of 25℃,A/O=2/1,the volume fraction of 30%,equilibrium time was 45 min.The extraction rate of Fe is 63.97% by using P507.Acetone method was more simple than extraction method.It can get pure Titanium Gypsum.So it can be used as the industrial production of the best method for removing iron application.