文章摘要
李红侠,孔德卉,朱强强,王胜男,汪振鹏.哌嗪香豆素衍生物的合成及抗菌活性研究[J].西昌学院学报(自然科学版),2019,33(3):8-11.
哌嗪香豆素衍生物的合成及抗菌活性研究
Study on Syntheses and Antibacterial Activities ofFluorine Piperazine Coumarin Derivatives
  
DOI:
中文关键词: 哌嗪香豆素衍生物  合成  抗菌活性
英文关键词: fluorine piperazine coumarin derivatives  synthesis  antibacterial activity
基金项目:宿州学院自然科学重点项目(2017yzd11);安徽省大学生创新创业项目(201810379002)。
作者单位
李红侠,孔德卉,朱强强,王胜男,汪振鹏 宿州学院生物与食品工程学院安徽宿州234000 
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中文摘要:
      以1-(2-氟苯基)哌嗪、1-(4-氟苯基)哌嗪分别与溴乙酸反应,所得产物再与4-羟基香豆素反应,合成哌嗪香豆素衍生 物A 和B,并研究其抗菌活性。A 和B 通过对倍稀释法测定其对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌和铜绿假单胞菌的 最小抑菌浓度。结果表明:A 和B 对所测试的4 种菌株均有较好的抑菌作用,其中B 的抑菌效果优于A,且对枯草芽孢杆菌的 抑菌效果最好,最小抑菌质量浓度为0.337 μg/mL,优于阳性对照氯霉素。
英文摘要:
      1-(2-fluorophenyl) piperazine and 1-(4-fluorophenyl) piperazine were used to interact with bromoacetic acid respectively to form derivatives which were again used to interact with 4-hydroxycoumarin to synthesize piperazine coumarin derivatives A and B, whose antibacterial activities were then studied. The minimum bacteriostastic concentrations of A and B against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa were determined through double dilution method. The results showed that both A and B had good bacteriostastic effects on the four bacterial strains tested, among which B was superior to A and produced the best bacteriostasis effect on Bacillus subtilis, and its minimum bacteriostastic concentration was 0.337 ug/mL, which was better than that of the positive control chloramphenicol.
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