Our objective is to study the composition changes of milk produced by female Meigu goats as the lactation time progresses, aiming to provide a theoretical basis for the timely weaning of kids and making good milk replacer. We employ the milk Composition Analyzer and automatic biochemical Analyzer to measure the regular ingredients in Meigu she-goat milk at different stages of lactation. The results show that milk ingredients of protein, lactose, ash content, non-fat-solids and mineral elements gradually decrease over time, then slightly increase on the 10th day, and then remain at a relatively stable level till the 30th day; there is no obvious regularity for the change of milk fat over time; strong correlations between protein and lactose, protein and ash, lactose and ash, iron and zinc, and calcium and phosphorus are found in our analyses of the relationships between various milk ingredients, and the optimal simulation equation between each pair is obtained. This study uncovers the changes of various milk ingredients and their mutual relationships at different lactation stages of Meigu she-goat, and provides the basic data for development of milk substitutes for Meigu goat kids.