At present, the MySQL database course has become one of the important professional courses for big data and computer majors in universities. However, as an emerging course, its teaching system is not yet perfect, and the teaching process often puts too much focus on the theoretical teaching, which makes the course tedious. To solve this issue as well as to achieve the goal of training application-oriented talents, this paper mainly discusses the case-driven multi-table connection teaching method,improves the design ofapplication-oriented teaching cases; stimulates students'learning interestand raises their practical ability with the MySQL application in big data.