The homogeneous charge compression ignition in the course of Automobile Engine Principles involves a large amount of chemical kinetic mechanism which is difficult for students to understand. We can build a simulation experiment model of homogeneous charge compression ignition with the software Chemkin. By modifying the corresponding parameters, different simulative results of heat release rate, in-cylinder temperature, and in-cylinder pressure under different initial conditions are discussed in groups. The fuel can be replaced by natural gas, and parameter variables and their effects are analyzed for the homogeneous charge compression ignition of natural gas engines. The simulation experiment model has stimulated students' interest and deepened their understanding of homogeneous charge compression ignition.