The experiment aims to optimize the propagation technology of potato stock seed under the ecological conditions in southwest Sichuan province. Quadratic orthogonal rotation combination design is used with decision variables of planting density (X1), organic fertilizer (X2), compound fertilizer (X3) and seed potato size (X4), and objective functions of yield per plant, plant height and yield so the mathematical model between each factor and the objective function can be established to develop the high yield cultivation model of Liangshan potato No.97. The results of mathematical model show that:(1) The ranking of different effects of each factor on potato yield per plant is as follows: compound fertilizer > seed potato size > density > organic fertilizer; ranking of the effects on plant height is: organic fertilizer > seed potato size > density > compound fertilizer; that on yield is: density > compound fertilizer > seed potato size > organic fertilizer. (2)The highest yield per unit area is 2 405.6 kg/667 m2 and the highest yield per plant is 0.55 kg/plant. Using DPS (V9.01 edition) to simulate optimization , the highest yield of 0.62 kg/plant is obtained with density 5 000 plants/667 m2, organic fertilizer 2 250 kg /667 m2, compound fertilizer 50 kg/667 m2, seed potato size 100 g; The highest yield of 2 489.78 kg/667 m2 is obtained with density 5 500 plants /667m2, organic fertilizer 2 250 kg/667 m2, compound fertilizer 50 kg/667 m2, and seed potato size 80 g.