Food safety regulation research in China has been evolving gradually. When drawing on experiences of developed countries, we need to compare the characteristic stage differences between China and developed countries, and consider the historical and cultural particularities and the political system of China. The regulation itself involves issues of legislation and enforcement, current problems, actual situation and effect, etc. We further demonstrate the superiority of multi-sector regulation to single-sector regulation, and the difficulty in coordination between sectors. Faced with widespread food safety problems, it's necessary to make in-depth investigations into the whole food industry. We included third-party forces (media, consumers, etc.) in the game framework, and analyzed the possibilities of food safety problems occurring in all parts of the complex food supply chain. Therefore, the social co-governance paradigm of food safety regulation has become a new direction of research.