In view of the characteristics of the observation data sequence of the settlement of the high-rise building, this paper focuses on the principle and characteristics of the discrete grey DGM (1,1) model combined with the project of a project in Xichang, and uses the Matlab as the simulation platform to apply the DGM (1,1) model to the settlement prediction of the high-rise building, and to test its prediction performance. The results show that the method can better simulate the development trend of settlement, and the error is small, which can meet the accuracy requirements and provide data support for later work.