The quality and ability of college students' innovation and entrepreneurship are in accordance with the requirements of the application oriented undergraduate colleges and universities. In this paper, combing with the Wuchang Shouyi University practice, based on innovation and entrepreneurship education, it proposed reform plan and the construction of the second classroom of Management course which is the platform course in College of Economy and Management, and carried out the depth of integration of the teaching processes and the innovation and entrepreneurship knowledge and practice.