To meet the needs of new economy and new industry, the development of new engineering, contract emerging industries and cultivating of new engineering talents is a current hot topic in the field of higher education and research front. This paper focuses on how to improve the innovative and entrepreneurial ability of new engineering talents in universities. First, it clarifies the current situation and existing problems of innovation and entrepreneurship. Taking Department of Health Management of Bengbu Medical College for example, this paper explores the training mode and the path of innovation and entrepreneurship education from curriculum, competition, innovation and entrepreneurship, incentive mechanism, school-enterprise cooperation and so on.