It can reduce environment pollution and make full use of resources to refine and recycle of active zinc oxide from zinc oxide flue dust. In accordance with ammonia complex method and leaching rate, this paper studied 6 factors influence on leaching rate ,which factors included ammonia, ammonium hydrogen carbonate, hydrogen peroxide, reaction temperature, reaction time and stirring speed. The frequency optimization research shows that leaching rate can reach 91.0% in the condition of 38.6℃～48.1℃reaction temperature, 377～446 r.min-1 stirring speed, 130.8～142.6 mL ammonia, 5.26～6.0 mL hydrogen peroxid, l.3～2.7 h reaction temperature, 28.3～ 38.3 g ammonium hydrogen carbonate.