Flue-cured tobacco is the primary economical plant along the An-ning River flatland. But the production of it is very poor for lack of scientifical cultivating measures. This experiment expliored the influences of multi-level combinations of nitrogenous,phosphate,potash fertilizers and manure,and corresponding cultivating measures upon the production of flue-cured tobacco. With the production value as an index for optimization of cultiavting measures,it provides scientific support for the cultivation and production of flue-cured tobacco along the An-ning River flatland.